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New Article About Brainz Power's Ingredient BACOPA MONNIERI LEAF & HERBAL EXTRACT

Specifically, in the last 50 years, Bacopa monnieri has been the focus of a great deal of scientific research on brain health, memory improvement, cognitive enhancement, and anxiety reduction.  This recent science is pointing to bacopa monnieri as one of the most powerful and natural nootropic substances you can find. We would speculate this is why you see it used in such a wide variety of traditional treatments.

The first is that bacopa is considered an adaptogen. You can think of adaptogen as any ingredient or chemical which helps your body overcome the effects of stress.

The second pathway is the ability of the bacosides (the active chemical compounds found in bacopa) to help improve the ability of your brain’s neurons to communicate. Bacosides also help promote better kinase functioning in your brain (the enzyme process of breaking down substances to be used by your brain cells). Think of protein kinases as the hallway monitor for your brain. They are the key regulators of cellular functioning.

With improved protein kinases you get help in repairing damaged brain cells and a boost in the creation of new brain cells which ultimately pays off with increased nerve impulse transmission (all hands on deck and working hard).

Bacopa’s primary role in helping improve your memory is by enhancing the way your brain communicates. Primarily, the bacosides delivered from bacopa help with the growth and repair of your brain’s nerve endings called dendrites. With more and better performing dendrites your brain’s ability to retain and recall memories should improve.

Bacopa also has a great effect on reducing anxiety and the incredibly harmful effects of chronic stress on your brain. We believe this is one of the most dangerous symptoms facing the world’s population today.

Conclusion:”There is some evidence to suggest that Bacopa improves memory free recall with evidence for enhancement in other cognitive abilities currently lacking perhaps due to inconsistent measures employed by studies across these cognitive domains. Research into the nootropic effects of Bacopa is in its infancy, with research still yet to investigate the effects of Bacopa across all human cognitive abilities. ”

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Science and Benefits Behind 1 of Brainz Power's 9 ingredients- N-Acetyl-L Carnitine HCI

The following Study is done by the US National Library of Medicine,

Mitochondria produce reactive oxygen species that may contribute to vascular dysfunction. Alpha-lipoic acid and acetyl-L-carnitine reduce oxidative stress and improve mitochondrial function. In a double blind, crossover study, we examined the effects of combined alpha-lipoic acid /acetyl-L-carnitine treatment and placebo (eight weeks per treatment) on vasodilator function and blood pressure in 36 subjects with coronary artery disease. Active treatment increased brachial artery diameter by 2.3% (P=0.008), consistent with reduced arterial tone. Active treatment tended to decrease systolic blood pressure for the whole group (P=0.07) and had a significantly effect in the subgroup with blood pressure above the median (151±20 to 142±18 mmHg, P=0.03) and in the subgroup with the metabolic syndrome (139±21 to 130±18 mmHg, P=0.03). Thus, mitochondrial dysfunction may contribute to the regulation of blood pressure and vascular tone. Further studies are needed to confirm these findings and determine the clinical utility of alpha-lipoic acid/acetyl-L-carnitine as antihypertensive therapy.

In addition to serving as the site of oxidative phosphorylation, it is now clear that mitochondria regulate many cellular functions, in part, by producing reactive oxygen species that signal the adaptive response to environmental stress and injury. Excess production of mitochondria-derived oxidants, however, may have maladaptive effects., There is growing evidence that disturbances of mitochondrial function, including increased oxidant production and altered mitochondria-dependent signaling contribute to the pathogenesis of vascular disease in atherosclerosis and cardiovascular risk factors.,,

On the basis of these observations, we hypothesized that an intervention designed to improve mitochondrial function would have beneficial vascular effects in patients with cardiovascular disease. Recent experimental studies have shown that administration of alpha-lipoic acid and/or acetyl-L-carnitine can reduce oxidant production and improve mitochondrial function in models of aging, Furthermore, these compounds reduce blood pressure and improve endothelial function in animal models of hypertension- and diabetes- The present study was designed to examine the effects of combined alpha-lipoic acid/acetyl-L-carnitine treatment on vascular function and blood pressure in patients with coronary artery disease.

This randomized, placebo-controlled, double blind crossover study demonstrated that combined alpha-lipoic acid/acetyl-L-carnitine treatment was associated with an increase in baseline brachial artery diameter. Furthermore, we observed a non significant trend for a blood pressure lowering effect of alpha lipoic acid/acetyl-L-carnitine in all subjects and a significant reduction in systolic blood pressure in subjects with systolic blood pressures above the median and in subjects with the metabolic syndrome. These findings suggest the possibility that these mitochondria-directed antioxidants reduce basal arterial tone, particularly in two clinically relevant subgroups. In contrast, we observed no effect of treatment on the dilator responses to increased flow, nitroglycerin, or ischemia (reactive hyperemia).

A prior study demonstrated a decrease in systolic blood pressure and a direct vasodilator effect in nailfold capillaries after treatment with oral L-carnitine (3g/d for 20days) in patients with digital vasospastic disease.An open-label study of patients with diabetic nephropathy, reported that long-term alpha lipoic acid treatment (600 mg/d for 18 months) prevented the increases in blood pressure and urine albumin concentration observed in control patients. Experimental studies have consistently demonstrated an anti-hypertensive effect of alpha-lipoic acid or L-carnitine in various rat models of hypertension, including spontaneously hypertensive rats,, uninephrectomized deoxycorticosterone acetate-salt (DOCA-salt) hypertensive ratsand salt-loaded Dahl and Wistar-Kyoto rats.,

Our study differs from several previous human studies that examined the effects of lipoic acid or carnitine on endothelial function. For example, Heitzer and colleagues observed an acute improvement in endothelium-dependent dilation of forearm microvessels following an intra-arterial infusion of lipoic acid (final concentration 0.2 mmoles/L) in patients with diabetes mellitus. Sola and colleagues recently reported improved brachial artery flow-mediated dilation following treatment with lipoic acid 300 mg/d for four weeks in young patients with the metabolic syndrome (mean age 46 years). Intravenous administration of L-carnitine (3 gram bolus) enhanced reactive hyperemia in patients with peripheral arterial disease. The apparent discrepancies between the results of those prior studies and the present study likely relate to the marked differences in dose, route of administration, vascular bed studied and/or patient population.

The mechanisms accounting for the increased brachial artery diameter and suggestive anti-hypertensive effects of alpha-lipoic acid and acetyl-L-carnitine in our study remain undefined. We observed no effect of treatment on serum lipids, glucose, and insulin, which might have influenced endothelial function or arterial diameter. Experimental studies indicate that alpha-lipoic acid and acetyl-L-carnitine play important and potentially synergistic roles in normal mitochondrial function, and that reduced levels of these compounds are associated with increased mitochondrial oxidant production.,, In addition, lipoic acid supplementation has favorable effects on cellular redox state and has been shown to decrease lipid peroxidation and cellular production of reactive oxygen species.,,, The effects of alpha-lipoic acid and acetyl-L-carnitine on oxidative stress which contributes to the pathogenesis and cardiovascular complications of hypertension suggests that these compounds may be useful adjuncts in treatment. In the present study, we investigated the possibility that these compounds reduced oxidative stress and inflammation, but observed no effect of treatment on urinary F2 isoprostanes or serum C-reactive protein. It is important to point out, however, that these systemic markers may not accurately reflect events in the vascular wall.

Despite the effects on blood pressure and basal diameter, it is notable that we only observed a trend for increased total serum carnitine following treatment. It is known that acetyl-L-carnitine and alpha-lipoic acid are rapidly metabolized in human subjects with plasma half lives of 4.2 hours and 30 minutes,respectively. Thus, it is likely that acetyl-L-carnitine and lipoic acid metabolites and/or tissue levels may be more relevant for the observed effects. Similarly, the lack of effect of treatment on urine F2 isoprostanes does not rule out an effect of active treatment on oxidative stress at the tissue level.

We observed a particular benefit of alpha-lipoic acid/acetyl-L-carnitine in patients with the metabolic syndrome. This syndrome of insulin resistance is associated with hypertension; improvement of insulin sensitivity could have an anti-hypertensive effect. Consistent with our findings, several experimental studies suggest a blood pressure-lowering effect in models of diabetes mellitus or insulin resistance.- Those results and our findings are consistent with the growing evidence linking insulin resistance to mitochondrial dysfunction

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Science and Benefits Behind 1 or Brainz Power's 9 ingredients- Phosphatidylserie

Bovine-derived PS (phosphatidylserine) has been shown to improve memory, cognition, and mood in the elderly. To date, most evidence suggests that soy-derived PS is not effective for ARCD.

Phosphatidylserine (PS) derived from bovine brain phospholipids has been shown to improve memory, cognition, and mood in the elderly in at least two placebo-controlled trials. In both trials, geriatric patients received 300 mg per day of PS or placebo. In an unblinded trial of ten elderly women with depressive disorders, supplementation with PS produced consistent improvement in depressive symptoms, memory, and behavior after 30 days of treatment.1 A double-blind trial of 494 geriatric patients with cognitive impairment found that 300 mg per day of PS produced significant improvements in behavioral and cognitive parameters after three months and again after six months.2

Most research has been conducted with PS derived from bovine tissue, but what is available commercially is made from soy. The soy- and bovine-derived PS, however, are not structurally identical.3Doctors and researchers have debated whether the structural differences could be important,4 , 5 but so far only a few trials have studied the effects of soy-based PS.

Preliminary animal research shows that the soy-derived PS does have effects on brain function similar to effects from the bovine source.6 , 7 , 8 An isolated, unpublished double-blind human study used soy-derived PS in an evaluation of memory and mood benefits in nondemented, nondepressed elderly people with impaired memories and accompanying depression.9 In this three-month study, 300 mg per day of PS was not significantly more effective than a placebo. In a double-blind study, soy-derived PS was administered in the amount of 300 or 600 mg per day for 12 weeks to people with age-related memory impairment. Compared with the placebo, soy-derived PS had no effect on memory or on other measures of cognitive function.10While additional research needs to be done, currently available evidence suggests that soy-derived PS is not an effective treatment for age-related cognitive decline

In a study of active young men, supplementation with phosphatidylserine increased the time the men could exercise until exhaustion by approximately 25%.
In a double-blind study of active young men, supplementation with 750 of soybean-derived phosphatidylserine per day for 10 days increased the time the men could exercise until exhaustion by approximately 25%.11 Longer studies are needed to determine whether this effect would persist with continued supplementation.
The Following Research was done by the University of Michigan, read more at the link below
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Benefits of L-Glutamine

Studies have shown that using glutamine-enriched formulas after surgery increased immune cell activity, shortened hospital stays, improved nutritional status, and reduced infections.

Glutamine, one of the most abundant amino acids in the body, supports the health of the cells lining the gastrointestinal tract and is important for immune function.1 Glutamine is depleted when the body is under stress, including the stress of surgery.2 Blood levels of glutamine decrease following surgery, and as they return to normal, their increase parallels the increase in immune cells.3 Two controlled trials have shown that the use of glutamine-enriched intravenous formulas, providing approximately 20 grams of glutamine per day, resulted in increased immune cell activity and shorter hospital stays.4 , 5 Double-blind studies report that patients receiving intravenous formulas supplemented with glutamine after surgery had better nutritional status and better health outcomes, including fewer infections and other complications, compared with patients receiving regular formulas.

The amino acid glutamine may benefit athlete’s immune systems. Double-blind trials giving athletes glutamine reported 81% having no subsequent infection compared with 49% in the placebo group.

The amino acid glutamine appears to play a role in several aspects of human physiology that might benefit athletes, including their muscle function and immune system.8 Intense exercise lowers blood levels of glutamine, which can remain persistently low with overtraining.9 Glutamine supplementation raises levels of growth hormone at an intake of 2 grams per day,10 an effect of interest to some athletes because of the role of growth hormone in stimulating muscle growth,11 and glutamine, given intravenously, was found to be more effective than other amino acids at helping replenish muscle glycogen after exercise.12 However, glutamine supplementation (30 mg per 2.2 pounds body weight) has not improved performance of short-term, high-intensity exercise such as weightlifting or sprint cycling by trained athletes,13 , 14 and no studies on endurance performance or muscle growth have been conducted. Although the effects of glutamine supplementation onimmune function after exercise have been inconsistent,15 , 16double-blind trials giving athletes glutamine (5 grams after intense, prolonged exercise, then again two hours later) reported 81% having no subsequent infection compared with 49% in the placebo group

The following information was provided from the University of Michigan, read more at the following link

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